![]() ![]()
0 Comments
Her2 postie received zalota4/19/2023 ![]() ![]() Participants were randomly assigned to receive either T-DM1 or T-DXd. The DESTINY-Breast03 trial enrolled 524 people with HER2-positive breast cancer that could not be removed by surgery or had metastasized to other parts of the body, including the brain. Trastuzumab Deruxtecan Improves Progression-Free Survival, Shrinks More Tumors “We were waiting for T-DXd to be compared to another treatment in a large clinical trial like ,” Dr. But that trial did not directly compare the drug with other treatments. Those results, which showed that tumors responded to T-DXd in about 60% of patients who had already received numerous prior treatments, “were already impressive,” Dr. The trial was funded by Daiichi Sankyo, Inc., and AstraZeneca, the developers of T-DXd.įindings from a smaller clinical trial called DESTINY-Breast01, which were published last year, led the Food and Drug Administration to grant accelerated approval to T-DXd as a treatment for people with inoperable or metastatic HER2-positive breast cancer who had received at least two prior lines of HER2-targeted treatment. The new study, a large international clinical trial called DESTINY-Breast03, is the first to directly compare T-DXd with another treatment in people with breast cancer. The ADC is then ferried inside the cell, where the attached chemotherapy drug is released. The trastuzumab component of both T-DM1 and T-DXd acts as a homing device that helps the drug deliver its chemotherapy “payload” directly to tumor cells that overproduce HER2. Such drugs consist of a monoclonal antibody, in this case trastuzumab, chemically linked to a cell-killing chemotherapy drug. As a result, researchers have been developing new drugs based on these antibodies.īoth T-DM1 and T-DXd, which are given by infusion into a vein, are drugs known as antibody–drug conjugates (ADCs). Trastuzumab and other drugs called monoclonal antibodies that target HER2 have been quite successful as treatments for HER2-positive breast cancer. Such HER2-positive tumors tend to grow faster and are more likely to spread elsewhere in the body, or metastasize, than those that do not overproduce HER2. ![]() In about 15%–20% of people with breast cancer, tumors overproduce HER2, with the excess HER2 on tumor cells driving the cancer’s growth. “In my 15 years of experience as a breast cancer clinician, I’ve never seen such a marked improvement in efficacy with a new drug compared to the current standard therapy for metastatic breast cancer, so it really is quite exciting for our patients,” Dr. ![]() The superior response to T-DXd was “very impressive” and suggests that this drug should be the new standard second-line treatment for such patients, said Alexandra Zimmer, M.D., clinical director of the Women’s Malignancies Branch in NCI’s Center for Cancer Research, who was not involved with the study. Twelve months after treatment started, the cancer was still under control in nearly 76% of people in the trastuzumab deruxtecan, or T-DXd group, compared with 34% of those treated with T-DM1, said senior study investigator Sara Hurvitz, M.D., of the UCLA Jonsson Comprehensive Cancer Center. Although the trial is ongoing, a planned interim analysis of data from the study showed a clear difference between the two treatments. Interim results of the clinical trial, which compared the two drugs in people whose disease had progressed after treatment with at least one earlier regimen for metastatic breast cancer, were presented September 18 at the European Society for Medical Oncology (ESMO) Congress 2021. Since 2013, trastuzumab emtansine, commonly abbreviated as T-DM1, has been the preferred second-line treatment for people with metastatic breast cancer that overproduces the HER2 protein, known as HER2-positive breast cancer. In a head-to-head comparison, trastuzumab deruxtecan (Enhertu) was also better at shrinking tumors than another targeted drug, trastuzumab emtansine (Kadcyla). The approval was based on the results of the DESTINY-Breast03 trial, details of which are discussed in the story below.Ī new targeted drug markedly lengthened the time that people with an aggressive subtype of metastatic breast cancer lived without their cancer progressing, new study results show. if they received the HER2-targeted therapy before or after surgery for early-stage breast cancer and their cancer returned during, or within 6 months of completing, that treatment.if their cancer has spread (metastatic) or cannot be treated with surgery.Under the approval, the drug can be used in such adults UPDATE: On May 4, 2022, the Food and Drug Administration (FDA) expanded the approval of trastuzumab deruxtecan (Enhertu) for the treatment of some adults with HER2-positive breast cancer who have previously received a HER2-targeted therapy. ![]() Ubuntu install phpmyadmin nginx4/19/2023 ![]() Open your text editor and create the following file: sudo nano /etc/nginx/snippets/phpmyadmin. In this guide we will create a snippet which we can include in any of our Nginx server block files. NET Core in Ubuntu 18.04 Music no 8 Install MySql Server: Install PHP. If your domain’s server block is already set up to serve the PHP requests then you can simply create a symbolic link from the phpMyAdmin installation files to your domain document root directory. How To Install Nginx, MySQL, PHP, PhpMyAdmin. There are several ways how to configure the Nginx to serve phpMyAdmin files. You can use any name you like, just be sure to set a strong password. In this example we named the administrative user padmin. Start by log in to the MySQL server as the root user: sudo mysqlįrom within the MySQL shell execute the following commands which will create a new administrative user and grant appropriate permissions: CREATE USER IDENTIFIED BY 'change-with-your-secure-password' GRANT ALL PRIVILEGES ON *.* TO WITH GRANT OPTION We will use this user to login to the phpMyAdmin dashboard and preform administrative tasks on our MySQL server. This user will have the same privileges as the root user and will be set to use the mysql_native_password authentication method. Instead of changing the authentication method for the MySQL user root, we will create a new administrative MySQL user. This means that you can’t authenticate as a root by providing a password. The auth_socket plugin authenticates users that connect from the localhost through the Unix socket file. In Ubuntu systems running MySQL 5.7 (and later), the root user is set to use the auth_socket authentication method by default. Next, run the following command to install the phpMyAdmin package from the default Ubuntu repositories: sudo apt install phpmyadminĪt this point phpMyAdmin has been installed on your Ubuntu server. Start by updating the packages list: sudo apt update Installing phpMyAdmin is a fairly simple task. If you don’t have SSL enabled on your sites, check our article about how to secure your Nginx with Let’s Encrypt on Ubuntu 18.04 Logged in as a user with sudo privilegesĪlthough not necessary, it is highly recommended to access your phpMyAdmin instance over HTTPS.LEMP (Linux, Nginx, MySQL, and PHP 7) installed on your Ubuntu server.Prerequisites #Įnsure that you have met the following prerequisites before continuing with this tutorial: This tutorial describes how to install phpMyAdmin with Nginx on Ubuntu 18.04. ![]() PhpMyAdmin allows you to interact with MySQL databases, manage user accounts and privileges, execute SQL-statements, import and export data in a variety of data formats and much more. ![]() How to INSTALL phpMyAdmin in Linux CentOS 7 with LAMP Stack ![]() ![]() ![]() "But this opportunity here was really difficult to turn down, and had nothing to do with the run they made to the Elite Eight. ![]() "A lot of blood, sweat and tears went into Wagner and building up that program," Mason said. That's the way Saint Peter's will be on the court, although Holloway had them doing that in knocking off Kentucky, Murray State and Purdue in the NCAA tournament. "But I fouled him a lot because I refused to get blown out." "He probably won most of them," Mason said of their matchups. Patrick, which became The Patrick School a decade ago. He frequently went head-to-head with Holloway, who attended St. Mason played two seasons at Marist High School for Chavannes and got to play against older players during the summer after his coach left for St. They got to play because both youngsters knew Chris Chavannes, the current coach at The Patrick School. Mason said he was in seventh grade when he first met Holloway, a fellow guard who never backed down. Paul refused to disclose details of Mason's contract with the Jesuit university, which has an undergraduate enrollment of about 2,100 students. Both men stress hard work, toughness and family. ![]() She ultimately said Mason was attractive because he reminded her of Holloway, who led the team to a 22-12 mark this past season and the Metro Atlantic Athletic Conference tournament title. He said that he's not there to shake things up and that he wants to take the program to new heights.Īthletic director Rachelle Paul said there was a lot of interest in the Saint Peter's job from all walks of college and high school coaches. ![]() Mason said he spoke Tuesday with the Peacocks, telling them that he is a worker and knows they are too. "I am just going to be open-minded to everything." "I am listening to all my options," said Banks, who led the Peacocks with 11.3 points per game. Ranking men's college basketball's top transfers: Where has everyone landed?īanks said that Mason tried to recruit him out of high school, so he knows him.Edert confirmed his decision to transfer. Holloway left two weeks ago for the job at Seton Hall, his alma mater.īanks, Lee and Edert were at the news conference in the refurbished Run Baby Run Arena along with Peacocks teammates and players from Wagner in Staten Island. "Getting the roster settled is what I'm focused on," Mason said Wednesday, shortly after being introduced as the Peacocks' new coach. Starting guards Daryl Banks III and Matthew Lee are in the transfer portal, and top reserve guard Doug Edert has decided to transfer to Bryant. 15 seed to reach the final eight in the NCAA tournament, and fan favorites across college basketball.Įven tougher for the 38-year-old Jersey City native, who spent the past decade at nearby Wagner, will be keeping the Peacocks' roster intact. He understands that replacing Shaheen Holloway will be a tough act to follow after the Peacocks became the first No. Bashir Mason is looking forward to the challenge of taking over at Saint Peter's after its incredible run to the Elite Eight. ![]() Axure rp 94/19/2023 ![]() ![]() Also, in RP10 you will be able to inspect the element in order to extract the CSS.
Webmin login4/19/2023 ![]() ![]() It supports multiple functions such as creating/managing Apache virtual hosts, MySQL database creation/management, generating DNS zones, managing mailboxes, and much more. Not sure if or how it could work in a shared environment.Virtualmin is a great open-source Webmin module typically used to manage multiple virtual hosts through a single interface, similar to cPanel. I've only done this on my own VPS with no other users. There are lots of how to's on the internet. Just stick to it and you will figure it out and realize it's not that complicated. If not don't be intimidated, it's not as hard as it first seems. If you are already using ssh keys and know how to set up Putty ssh tunnel this should be trivial to set up. You still have to log into the GUI with root password but for administration it should not be much of an inconvenience and is an extra layer of security. Now the only way to get to Virtualmin/Webmin GUI login prompt is with SSH tunnel using putty or some other SSH client and if PasswordAuthentication is set to no then the only way to do that is with ssh keys. After confirming that works go into /etc/ssh/sshd_config and set "PasswordAuthentication no" if it isn't already. Set Webmin to only listen to 127.0.0.1 in the Webmin GUI at Webmin>Webmin Configuration>Ports and Addresses. When it's working you should be able to open a browser to and get your Virtualmin/Webmin server GUI. Create a SSH tunnel to your server on port 10000 (or whatever your Virtualmin/Webmin port is) using Putty. Here is the solution if you want to secure with SSH keys. The user would then log in using their username and the token. Of course, they would need to be kept secure (readable only by root), they would need to have some sort of reasonable expiration time and should probably be limited to one per user. This could be stored in a database, in the filesystem or in memory. ![]() This would be a bit more inconvenience for the user, however in order to log in to Webmin, they first need to log in by SSH and generate a single use token by executing a script on the server. Require a single use token generated by SSH. The public key would then be authenticated as it is in SSH connections. Alternatively, the user could copy/paste the contents of their public key into the browser if the above method wouldn't be feasable. We would need to use some tricky Javascript (tricky for me anyway) that would allow the user to select their private key from their file system and, using the passphrase, generate the respective public key client-side and send it to the server along with their username. Make the user upload the public key to the server using the browser. Here are a couple of ideas I came up with how this could be accomplished. It would be nice if we could somehow make use of the public key authentication system already in place in order to authenticate users through Webmin/Virtualmin. Because of this, I usually have Webmin disabled and enable it only when I want to use it. I have a server running Webmin and Virtualmin, however one small gripe I have is that enabling an SSH server with public key authentication and disabling password authentication is essentially defeated by enabling Webmin since it only allows password authentication and provides many functions that a user could do to authenticate themselves with full SSH access (such as a file manager for basic users and editing the sshd_conf file for root). ![]() Lugaru terrain overgrowth4/18/2023 ![]() ![]() The game has full support for mods, so it can be expanded and co-created by the players themselves. For music for the Amnesia and Penumbra series. The author of the soundtrack for the game is Finnish composer Mikko Tarmia, responsible, among others. The texture is 2048×2048 resolution and realistic, dynamically changing lighting in the graphics. The weather is also influenced by the weather. Thanks to this, the transition between running, jumps or perversions is exceptionally smooth, and animations depend on the circumstances, terrain, mood and even personality of the hero. It is characterized by a refined animation based on physics. The game was announced in September 2008, while its relatively long production cycle was primarily used to improve the engine’s engine name Phoenix Engine. For example, a hero can use a tree branch to deflect a branch, or cross the river to lose a wolf hunting him. Turner can use a wide assortment of white-on-white weapons and also has the ability to bounce punches so that almost every attack is able to turn against an attacker.Īn important element of the game is the ability to use the environment. ![]() It is based on cautious attacks, upheavals and high mobility of characters. During exploration our protagonist will have to face a variety of opponents, using a specially designed and original combat system. ![]() But he refuses to take his place on the throne, embarking on a journey of repairing the world. The main character, Turner, after killing the evil and corrupt king is called the new ruler of the land. The action takes place several years after the events of the Lugar. The universe is inhabited by atypical anthropomorphic warriors such as rabbits, wolves, dogs, cats and rats. The plot of the game is set in a medieval, dystopian world, dominated by anarchy and lawlessness. Overgrowth is the original third-person action game created by the independent American studio Wolfire Games, created on the initiative of David Rosen – award-winning uDevGames in the category of the best game developer on Mac OS X.īoth in terms of feature and technological title is the development of the first amateur Production studio, Lugaru, which appeared in 2005 for PC and Mac. The game uses a physics-based engine, as well as a specially designed combat system. The main character refuses to take over the throne after killing a corrupt king and embarks on a dangerous journey to repair the anarchy and the lawless world. Original third-person action game embedded in a dystopian world inhabited by anthropomorphic warriors such as rabbits, wolves, dogs, cats and rats. ![]() Easy duplicate finder 5.4 torrent4/18/2023 ![]() ![]() Rather than finding them manually, wouldn't it be easier to use a tool that can find them for you and delete them?After the scan process is finished . Easy Duplicate Finder 5.27 license key crack full is a great tool that . Easily find out your unnecessary same files and folders to delete this tool is perfect for that. Easy Duplicate Finder License Key Serial > DOWNLOAD (Mirror #1) d77fe87ee0 How to Activate Easy Duplicate Finder by Email. Easy Duplicate Finder Crack Easy Duplicate Finder Crack Free Download has important features that will help you find and remove duplicate photos, documents . Easy Duplicate Finder is an award-winning tool that will help you find and delete all sorts of duplicate . Downloads: 2565, Size: 12.11 MB, License: Shareware. Easy Duplicate Finder Crack 2021 comes with a quick setup process even offers a rather speedy scan algorithm. Easy Duplicate Finder Serial Key - Duplicate File/Folder Finder Pro Upcoming Features: Easy Duplicate Finder 5.22 License Keys: What New In . Find and delete duplicate files in seconds with Easy Duplicate Finder! With this tool you can. of Duplicate Photo Cleaner Keygen is better them all other duplicate finder software. a totally new methodology with this you can locate duplicate photos easily. This award winning duplicate files comparison program, supports unlimited number of files, folders, . Easy Duplicate Finder Crack is one of the best software. Easy Duplicate Finder 7.7.0.20 Crack+ License Key Free Download 2021 . Duplicate Files Fixer 2021 Crack is easy to understand and is. easy duplicate finder 4 torrent easy duplicate finder 4.3.0.181 crack . Filename: advanced duplicates finder crack By: thersoftti Spееd: 5 Mb/s. Requires: Win 10 / 8 / 7 / Vista / XP Downloads: 57102 . Easy Duplicate Finder will help you to find and delete duplicate files easily. ![]() Download Easy Duplicate Finder Serial on. Easy Duplicate Finder 2020 Crack Plus License Key presents accomplishment for overall intent, totally free and the user program. Simple installation with an intuitive user . Capable to scan USB, Floppy Disk, and more. ![]() ![]() Also, preview images in the application itself. How do you think, what hard disk space on your PC is occupied .ĭifferent support of formats. Easy Duplicate File Finder is a free powerful tool, that helps you to find and delete duplicate files. Easy Duplicate Finder has a comprehensive scanner that searches all the hard drive files and documents and identifies duplicate data. Crack With Keygen Key Download 2020: Easy Duplicate Finder has been trusted by millions of users to find .Īshisoft Duplicate File Finder Crack Plus Serial key Free Download Review:You may not really recognize how several duplicate data files you . The License is lifetime and all updates to the Duplicate Cleaner 4 series are included in price. An easy to use interface helps you tell Duplicate Cleaner where to look and what to look for. easy duplicate finder licence keyĮasy duplicate finder licence key, easy duplicate finder licence key free, easy duplicate finder licenceįind and remove duplicate files with Duplicate Cleaner, the premier free and pro solution. With this tool, you can recover gigabytes of space. With easy duplicate finder 5.28 Crack you can find and delete duplicate files in seconds. or Enter an activation key from an order confirmation email (you don't . Gemini 2 is an intelligent duplicate finder that frees your Mac from. Duplicate Files Fixer Crack with License Key Full Free is a duplicate file finder & remover app that scans and deletes all types of duplicate files from . App License: Open Source (GPL) Source: Duplicate Files Finder, . It's even better with the Platform for easy installs and automatic updates. Easy Duplicate Finder has a powerful scanner that scans all the files and folders on the hard drive .ĭuplicate Files Finder is an application which searches for duplicate files (files. Get easy duplicate finder license key crack. Easy Duplicate Finder is an award-winning tool t.sy Duplicate Finder is accurate . Using crack, password, serial numbers, registration codes, key generators, cd key. Duplicate Finder is a precision software program created to help you. Therefore, the tool has a fully based user interface and easy to follow any kind of wizard . Easy Duplicate Finder Licence Key ►►►►► DOWNLOADĠ.2 Crack is the tool that use to locate and also delete the unwanted files. ![]() Castle wolfenstein enemy territory mac4/18/2023 ![]() ![]() But Wolfenstein: Enemy Territory Single-Player - Vanilla Plus Edition brings back the true vanilla interface, allows use of vanilla-exclusive Wolfenstein: Enemy Territory Single-Player addons, such as the console ports interface and sounds, Wolfenstein: Enemy Territory sounds and fire-rates (new), etc. ![]() ![]() Of course, you can still get a proper vanilla experience by just installing the RealRTCW - Vanilla Plus edition, and playing Wolfenstein: Enemy Territory Single-Player through that same installation. Well, it's because Wolfenstein: Enemy Territory Single-Player - Vanilla Plus Edition goes deeper into the vanilla conversion optic. Today, I'm happy to announce its imminent release, and provide some more details!įirst of all, you may wonder what's the purpose of releasing it at all now that the new RealRTCW - Vanilla Plus edition is out, and it does splendidly work with addons. Warbell is coming early 2023 for Wolfenstein: Enemy Territory Single-Player & Cooperative.īack in May, I also announced Wolfenstein: Enemy Territory Single-Player - Vanilla Plus Edition, an optional addon for Mod DB's RealRTCW 4.0 version of the mod, and standalone Workshop release for Steam's, for those who want to experience the mod with standard/classic models and visuals instead of new ones, while preserving exciting modern features - such as achievements, expanded arsenal, rebalanced gameplay, etc. Blazkowicz and his squad mates return, to face some familiar faces who somehow managed to come back from the grave! Set after the events of Return to Castle Wolfenstein and the Central Europe campaign of Wolfenstein: Enemy Territory Single-Player & Cooperative, and based on the scenario of Warbell's remaster, the conversion's story will see B.J. It fits Return to Castle Wolfenstein so much that it almost feels like a continuation, and not just an excellent tribute. Originally developed by Matthias 'McNite' Neiss, Warbell is simply one of the best occult-themed Wolfenstein: Enemy Territory maps ever released. This doesn't mean, however, that I'm forgetting about KeMoN's previous works - their conversions are being worked on as we speak. I figured the timing's perfect to announce its single-player and cooperative conversion, since the plan is now to release said adaptations in parallel to KeMoN's releases. KeMoN's outstanding Warbell remaster was just recently released for ET: Legacy. Today, I'm excited to announce the first conversion project that will be released: Warbell. Six months ago, I announced a partnership with the very unique Wolfenstein: Enemy Territory mapper and friend KeMoN, one that allows me to use the sources for his various maps and remasters for potential story-driven conversions for Wolfenstein: Enemy Territory Single-Player & Cooperative. Today is yet another special day! It not only marks Return to Castle Wolfenstein's 21st anniversary, but also Wolfenstein: Enemy Territory Single-Player's very first! As usual, such milestones require proper celebration with exciting new announcements! Get Psyched!Īnnouncing 'Warbell' expansion - coming early next year! ![]() Joy pony game play online4/18/2023 ![]() Gameplay: 4During the Joy Pony game, you are invited to take care of cute horses.įantage. What is happening on the screen is really of great interest, and a variety of details will not let you get bored. There is peaceful music that accompanies the Joy Pony gameplay. Graphics: 4The graphics in the game are very bright and colorful. Play thousands of free online games for kids, get access to free. On the internet and on your mobile phone. Enjoy!We strive to deliver the best gaming experiences. We also add new games daily to ensure that you won't get bored of playing old games again and again. ![]() Pony games on this page are sorted according to users' rating, a game with the highest score is listed at first, so it's easy to find a good Pony game on the web. All these games can be played online directly, without signup or download required, but if you prefer to play games offline, you can also download any game file to your PC. We have chosen the best which you can play online for free. Catch all the magic with Pinkie Pie, Flutter Shy, Twilight Sparkle, AppleJack, Rainbow Dash, and Spike. Use your mouse as a paintbrush, and bring the lovable characters to life!Puzzle-solving players can have tons of fun testing their memory and searching for hidden letters!My Little Pony Friendship is Magic online is the place for My Little Pony games for kids and printable activities!Enjoy hours of creativity with your favorite Pony friends doing coloring pages, solving puzzles, designing dresses, and more!There are all Pony games on, such as, My Little Pony Equestria Girls, MLP Equestria Girls, Equestria Team Graduation, Bratz Babyz Ponyz Styling and The Cute Pony Care 2.įollow your favorite ponies in their latest adventures in Ponyville on My Little Pony Friendship is Magic. For blossoming artists, we have coloring adventures that feature scenes from the Friendship Is Magic television series. ![]() Girl gamers can play a cartoon version of Tetris filled with rainbow hearts and pink pieces. ![]() For a magical touch, add a unicorn horn and pair of fluttering wings!Fans of different game genres will love our broad selection of. Players will mix and match various fur colors, decorations, and accessories to give each mini-horse their own style. Several titles feature unique dress-up challenges, which allow you to customize your own creature. You can play with colorful, lovable ponies like Rainbow Dash, Twilight Sparkle, and Apple Bloom! Our collection of My Little is filled with adorable Hasbro dolls and TV show characters. This group is a public forum and opportunity for FB members to actively participate in networking. Mini or Pony in Kill Pens or Rescue has 4,171 members. ![]() AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |